Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease
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چکیده
منابع مشابه
The Protective Effects of Citrus Aurantium Extract in A 6-Hydroxydopamine-Induced Model of Parkinson\'s Disease in Male Rats
Introduction: Parkinson's disease (PD) is a commonly diagnosed neurodegenerative disease among the elderly. Considering the limited symptomatic improvement associated with PD treatments, introduction of more effective agents is necessary. Citrus aurantium flower extract (CAE) is recognized as a neuroprotective and hepatoprotective agent with bioactive compounds, such as flavonoids, phenolics, a...
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Introdution: Parkinson's disease is the second most common neurodegenerative disease. Considering the antioxidant and neuroprotective properties of chlorogenic acid, the purpose of this study was to evaluate the neuroprotective effect of this substance in an experimental model of Parkinson's disease. Methods: In this experimental study, Wisar male rats (n = 32) were divided into 4 groups: sham...
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Background and Objective: Parkinson's disease (PD) is an age-related neurodegenerative disease with selective damage of dopaminergic neurons of the mesencephalon. L-dihydroxyphenylamine (L-DOPA) therapy is currently the gold standard maneuver for PD. Due to the protective, anti-inflammatory, and antioxidant effect of sesamin, this study was undertaken to assess dose-dependent effect of this age...
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Introduction: Transplantation of embryonic ventral mesencephalic (VM) dopamine neurons into the striatum is a currently explored therapeutic strategy for treatment of patients with patients with Parkinson's disease (PD). However, this strategy has been limited with poor cell survival, generally ranging from 5-20%. In this study, we investigated the effect of potassium channel blocker of tetr...
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ژورنال
عنوان ژورنال: npj Parkinson's Disease
سال: 2015
ISSN: 2373-8057
DOI: 10.1038/npjparkd.2015.10